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Fig. 1
Recovered patients with massive hepatocyte loss–induced liver failure (MHL-LF) robustly express hepatocyte nuclear factor 4α (HNF4α) in either liver progenitor cells (LPCs) or hepatocytes. (A) Serum total bilirubin (TBIL), international normalized ratio (INR), and the Model for End-stage Liver Disease (MELD) scores are compared between 5 survivors and 5 patients with irreversible MHL-LF receiving liver transplantation (LTx). (B) Immunohistochemical staining for HNF4α was performed in these patients. Yellow and red arrows depict negative or positive HNF4α expression in LPCs. (C) Positive HNF4α hepatocytes and LPCs were counted in the collected patients, as described in Materials and Methods
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