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Fig. 1
Recovered patients with massive hepatocyte loss?induced liver failure (MHL-LF) robustly express hepatocyte nuclear factor 4? (HNF4?) in either liver progenitor cells (LPCs) or hepatocytes. (A) Serum total bilirubin (TBIL), international normalized ratio (INR), and the Model for End-stage Liver Disease (MELD) scores are compared between 5 survivors and 5 patients with irreversible MHL-LF receiving liver transplantation (LTx). (B) Immunohistochemical staining for HNF4? was performed in these patients. Yellow and red arrows depict negative or positive HNF4? expression in LPCs. (C) Positive HNF4? hepatocytes and LPCs were counted in the collected patients, as described in Materials and Methods
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