ZFIN Image: Shi et al., 2023, Figure 2

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Figure Caption

Figure 2

Molecularly distinct cell types between the zebrafish inner ear and lateral line.

Ear and lateral line cells were selected from a whole-embryo single-nucleus RNA-seq dataset from animals between 18 and 96 hpf using known marker genes for hair cells and supporting cells. (A–B) UMAP projection of inner ear and lateral line cells grouped by (A) developmental timepoint and (B) broad cell type: ear nonsensory SC (red), lateral line nonsensory SC (green), ear HC (blue), and lateral line HC (yellow). Clusters in (B) correspond to columns of following gene expression plots. Widely accepted marker genes for (C) inner ear nonsensory cells, (D) lateral line nonsensory cells, and (E) hair cells show enriched expression in the corresponding clusters from B, confirming their identity. (F) Expression of previously identified marker genes for inner ear or lateral line hair cells was used to identify hair cell origin.

Acknowledgments

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