(A) Illustration of the lateral line system of a 5 dpf zebrafish. Blue circles represent individual neuromasts located on the body of the fish. Boxed region indicates location of the ear. (B) Enlarged diagram of the 5 dpf zebrafish ear showing cristae (red) and macular (blue) sensory organs. (C,D) Illustrations of adult zebrafish and mouse inner ears showing homologous end organs in the semicircular canal crista ampullaris (red) and macula otolith organs (blue). Light green and dark green represent unique end organs of the lagena in zebrafish and cochlea in mice. (E) Illustration of the mouse utricle showing striolar and extrastriolar regions of the sensory organ. Arrows represent hair cell planar polarity within the sensory organ and red dashed line represents the line of polarity reversal within the striola. ac: anterior crista, c: cochlea, l: lagena, lc: lateral crista, o: otolith, pc: posterior crista, s: saccule, u: utricle.
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