ZFIN Image: Rocha et al., 2021, Fig. 6

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Figure Caption

Fig. 6 Cdx4 function is not necessary in the somitic mesoderm. A. Schematic of the transplantation approach to generate chimeric embryos with Cdx4-deficient cells in the somites. B-E. Lateral image of NC migratory streams (magenta), cell nuclei (green) showing the overall morphology of a 25 hpf chimeric embryo with Cdx4-deficient cells (cyan) in the somites. Scale bar = 150 μm. Arrowhead indicates donor cells at the myoseptum. B’-E’. Higher magnification images of boxed region from B-E. Scale bar = 50 μm. F. Schematic of the transplantation approach to generate chimeric Cdx4-deficient embryos with WT cells in the somites. G-J. Lateral image of trunk NC cells (magenta), cell nuclei (green) showing the overall morphology of a 25 hpf chimeric Cdx4-deficient embryo with WT cells (cyan) in the somites. Scale bar = 150 μm. G’-J'. Higher magnification images of boxed region from G-J. Scale bar = 50 μm.

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Reprinted from Developmental Biology, 480, Rocha, M., Kushkowski, E., Schnirman, R., Booth, C., Singh, N., Beadell, A., Prince, V.E., Zebrafish Cdx4 regulates neural crest cell specification and migratory behaviors in the posterior body, 25-38, Copyright (2021) with permission from Elsevier. Full text @ Dev. Biol.