ZFIN Image: Sarmah et al., 2022, Fig 6

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Figure Caption

Fig 6

Dysregulation of extracellular matrix proteins in Elf3 morphants.

(A) IPA predicted direct relationships and downstream targets of Elf3. (B-D) In situ hybridization detecting sox9b expression at 2 dpf show strong expression in the retina, brain ventricular zone, craniofacial cartilages, and pectoral fin in the control embryos (B) and weaker expression in those areas in the morphants (C, D). arrow: developing craniofacial cartilages. (E) Quantitative RT-PCR assays comparing transcripts of mmp13, mmp9, mmp2, fn, and col2α1 (average fold change from at least 3 independent experiments) show altered levels of expression of those genes in morphants compared to control, Student’s t-test: P<0.05. Scale bar for B-D = 200 μm.

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Acknowledgments

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