ZFIN Image: Jimenez et al., 2022, Figure 6.

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Figure Caption

Figure 6.

Combinatorial accessibility of Six and Sox TFs are defined by distinct cell identities

(A) Pairwise predicted TF co-association in SCs, PCs, and HCs. x and y axes show significantly enriched predicted TF binding sites. Gray boxes represent lack of co-association between the TFs, whereas the colored boxes represent co-association. Correlation of TFBSs p < 0.001.

(B) Sox and/or Six TF motif containing enhancers associated with differentially expressed genes in SCs, PCs, or HCs. Categories of TF containing motifs include Sox containing, Six containing, Sox and Six containing, or neither.

(C) Model of Six and Sox TFs with cooperative roles functioning as either stem cell promoting or HC promoting factors.

Acknowledgments

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