ZFIN Image: Niescierowicz et al., 2022, Fig. 2

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Figure Caption

Fig. 2

a Wild-type (b, c) Adar MO-injected embryos develop abnormal phenotype in the posterior part with disturbed body axis, shortened tail and crooked, disorganized notochord. d MO phenotype can be fully rescued with wild-type mRNA injection. e Mutant adar mRNA E1030A with inactivated editing domain could not rescue the malformed phenotype. f, g Phenotype defects caused by adar mRNA overexpression. The anterior defects, including cyclopia and head malformations are mRNA dose dependent. Inset marked by red boxes denotes overlaid identical image taken at different focal plane. Observation was performed on embryos from four independent adult pairs with similar results. h, i Injection statistics of Adar MO, rescue, and mRNA overexpression. Source data are provided in the Source data file.

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Phenotype details

Acknowledgments

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