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Fig. 3
Effect of clemizole and trazodone on ictal-like seizure events in stxbp1b mutant zebrafish. A, Individual value plot of ictal event frequency at baseline (0–15 min) and 45–60 min after continuous bath application of 1 mM clemizole (CLM, n = 11). Independent experiment pairs are indicated by the connected line. ***P < .0001. B, Representative 60-min local field potential (LFP) traces for stxbp1b mutant zebrafish at baseline (6.5 ± 0.6 events/15 min) and 45–60 min after clemizole exposure (1.3 ± 0.3 events/15 min). Ictal events are noted by open red circles above traces. C, Individual value plot of ictal event frequency at baseline (0–15 min) and 45–60 min after continuous bath application of 1 mM trazodone (TRZ, n = 14). Independent experiment pairs are indicated by the connected line. ***P < .0001. D, Representative 60-min LFP traces for stxbp1b mutant zebrafish at baseline (8.2 ± 1.4 events/15 min) and 45–60 min after trazodone exposure (1.4 ± 0.4 events/15 min). Ictal events are noted by open red circles above traces. Student’s unpaired t tests
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