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Fig. 9
An evolutionarily conserved GATA4/5/6 regulatory axis regulates cardiac and pharyngeal mesoderm fate balance.
(A) Loss of Gata4/5/6 family TFs in zebrafish and Ciona results in a bias to a pharyngeal fate, which requires down-regulation of Gata4/5/6 expression in a WT-like context. (B) Gata5/6 promotes the accessibility of enhancers near cardiac genes (e.g., gata4, tbx20, and hand2) while repressing that of the pharyngeal enhancers (e.g., tbx1, ebf2, and ebf3a) in the precardiac mesoderm. In the pharyngeal mesoderm, where gata5/6 is down-regulated, the repression of the pharyngeal enhancers is removed.
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