ZFIN Image: Fu et al., 2022, Fig. 4

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Fig. 4

Fig. 4. Rspo1 is required for MNU-induced abnormal angiogenesis. A. Representative images of ISV and hindbrain vessels from control group, MNU-treated group, rspo1 MO-treated group and MNU-treated rspo1 MO group at 48 hpf. White arrows point to ectopic ISV branches. To better observe the phenotype, the concentration of rspo1 MO used was 150 μM for imaging analysis. Red arrows indicate the central artery (CA). Scale bar, 50 µm. B. Quantitative analysis of ectopic intersegmental vessel (ISV) branches in control group, MNU-treated group, rspo1 MO-injected group and rspo1 MO plus MNU-treated group at 48 hpf. Data were obtained from three independent experiments and are expressed as the mean ± SEM. * ** * P < 0.0001, * * P < 0.01, * P < 0.05.

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Acknowledgments

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