ZFIN Image: Wolińska-Nizioł et al., 2022, Fig. 4

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Figure Caption

Fig. 4

Deficiency of Tollip does not worsen the phenotypic hallmarks of Gaucher disease in the zebrafish model. (A) The general phenotype of zebrafish adults (3 mpf) of the examined mutant genotypes (tollip ^+/+/gba1 ^−/−; tollip ^−/−/gba1 ^+/+; tollip ^−/−/gba1 ^−/−), compared to the wild‐type genotype (tollip ^+/+/gba1 ^+/+). Scale bar 1 cm. (B) Swimming velocity examined in the mutant and wild‐type lines. Data are averaged within the tested groups, triangles indicate individual fish (n = 8 for the tollip ^+/+/gba1 ^+/+, tollip ^+/+/gba1 ^−/−, tollip ^−/−/gba1^+/+/ groups, n = 10 for the tollip ^−/−/gba1 ^−/− group) and the error bars represent SEM. t‐test, ns.—nonsignificant, **P < 0.005, ***P < 0.001.

Figure Data

Phenotype details

Acknowledgments

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