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Fig. 2
sgo1−/− show functional heart defects at 5 dpf. (A) Heart rate measurements in sgo1+/+, sgo1+/−, and sgo1−/− larvae at 3 dpf (sgo1+/+ n = 13, sgo1+/− n = 26, sgo1−/− n = 13). (B) Heart rate measurements in wild type, heterozygous carriers and homozygous mutant larvae (5 dpf; sgo1+/+ n = 25, sgo1+/− n = 36, sgo1−/− n = 10). (C) Kymograph of beat-to-beat distances in wild-type, heterozygous carriers and homozygous mutant larvae (5 dpf). (D) Sample images of the ellipse taken at end diastolic volume (EDV) and end systolic volume (ESV). Measurements using EDV/ESV ellipse methods for wild-type, heterozygous carriers and homozygous mutants at 5 dpf include: (E) EDV, (F) ESV, (G) ejection fraction (EF), (H) stroke volume (SV), and (I) cardiac output (CO). All measurements were performed in two biological replicates. Statistics: mean ± SEM, P ≤ .05, ***P ≤ .001, ****P ≤ .0001, n.s. P > .05, one-way ANOVA. Bmp: beats per minute, pL: picoliter, nL/min: nanoliter per minute, mm2: square millimeter
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