Fig. 5
Upregulated Fmnl2 and altered gliovascular interactions observed in chronic APP/PS1dE9 AD model in mice. a, h Triple immunohistochemical stainings (tIHC) for Gfap (astroglia), 4G8 (amyloid plaques) and Fmnl2 with DAPI counterstain in control (a, d) and APP/PS1dE9 mice (e?h) at 12 months of age. Panels are from cerebral cortex. Black-white panels are individual fluorescence channels of the composite images in a and e. i?p tIHC for Gfap, Cd31 (blood vessel) and Fmnl2 with DAPI counterstain in control (i?l) and APP/PS1dE9 mice (m?p) at 12 months of age. Panels are from cerebral cortex. Black-white panels are individual fluorescence channels of the composite images in i and m. Scale bars as indicated