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Figure 6
The CLVS1 p.H310Y variant decreases clavesin-1 ligand binding to α-tocopherol transport protein.
(A) The p.H310Y change is predicted to cause major structural alterations to the C-terminus of clavesin-1 and interfere with α-tocopherol–binding domain (white arrow). (B and C) Coimmunoprecipitation studies revealed a decrease in Myc-tagged clavesin-1 bound to the immunoprecipitated Flag-tagged αTTP when both are expressed at equivalent levels in HEK293 cells (n = 3, P = 0.006, 2-tailed t test).
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