ZFIN Image: Monroe et al., 2022, Fig. 1

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Fig. 1

Induction of transgenes causes rapid oncogenic transformation of normal zebrafish liver cells into HCC cells. Representative histological cross sections of 3-month post-fertilization (mpf) DOX-treated zebrafish liver tissue from 1.5 to 7.5 dpt. Images were taken at 40× magnification. A x−m−, non-transgenic control; B x+m−, xmrk oncogene expression; C x−m+, Myc oncogene expression; D x+m+, xmrk and Myc oncogene expression. Key: black arrows, apoptotic cells; black boxes, syncytial cells with multiple nuclei indicating abnormal mitosis. Error bars = 20 μm

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