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Figure Caption
Fig. s4 Generation of a dio2 mutant allele. (A) Diagram of Dio2 protein sequence showing location of sgRNA target site (red arrow) within the deiodinase domain. Numbers indicate amino acid position relative to start codon. (B) Genomic location and genetic lesion of the dio2 mutant, which leads to a frameshift followed by 6 novel amino acids and a premature stop codon. sgRNA target sequence indicated with red text.
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Reprinted from Developmental Biology, 477, Aman, A.J., Kim, M., Saunders, L.M., Parichy, D.M., Thyroid hormone regulates abrupt skin morphogenesis during zebrafish postembryonic development, 205-218, Copyright (2021) with permission from Elsevier. Full text @ Dev. Biol.