ZFIN Image: Berger et al., 2022, Fig 6

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Figure Caption

Fig 6 Residual sarcomeres assemble within <italic toggle='yes'>capza1a</italic> and <italic toggle='yes'>capza1b</italic> depleted zebrafish.

(A) At 2 dpf, Lifeact-GFP (green) and mCherry-CaaX (red) highlighted the sarcomere organisation and myofibril striation within muscle fibres of WT siblings. In two out of four analysed capza1b^ex5 homozygotes, thin filament deposits (arrows) were detected at the peripheral ends of some fibres. Although myofibril striation (arrowheads) was detected in capza1b^ex5 homozygotes that were hetero- or homozygous for capza1a^ex5, thin filament deposits (arrows) were frequently located at the peripheral myofiber ends. (B) At 2 dpf, highly organised sarcomeres were found on transmission electron micrographs of siblings and capza1a^ex5;capza1b^ex5 compound homozygotes. However, electron-dense aggregates with a lattice structure (arrowheads) and filament deposits (star) were present close to the myosepta (arrow) in the compound homozygotes. Scale bar sizes are indicated.

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Acknowledgments

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