ZFIN Image: Karuppan et al., 2021, Figure 9

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Figure Caption

Figure 9

A model illustrating how a CNTN–amyloid complex would mediate interactions with receptors expressed on specific target cells.A, CNTN3–5 form cis complexes on axonal surfaces as well as the surfaces of target cells. The flexibility of the linker regions between the E1 and the E2 domains of APP, APLP1, and APLP2 makes it possible to bind to the second FN domain of CNTNs on the same cell or on an apposing cell. Alternatively, a CNTN–amyloid pair on axons could interact with an as of yet unknown partner on the target surface (B). APLP1, amyloid beta precursor like protein 1; APLP2, amyloid beta precursor like protein 2; APP, amyloid precursor protein; CNTN, contactin; FN, fibronectin type III repeat.

Acknowledgments

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