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Figure 2 -
Fig. 2. GDF11 is conserved across species. (a) GDF11 is highly conserved, sharing very high DIOPT scores with mice, fish, and flies. (b) Both the missense variants (p.R298P and p.E306K) modeled in this study affect conserved amino acids in Drosophila. (c) Both missense variants lie within the Furin cleavage site or the TGF-β signaling domain of GDF11 and its homologs.
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