Fig. 2

Fig. 2 Positional cloning of psr. (A) Region of Chr21 to which psr was mapped using polymorphisms identified in AB^wp and wik backgrounds. Informative markers and recombinants relative to psr^utr8e1 phenotype are shown above chromosome. Positions of causal substitutions below, relative to zebrafish whole genome assembly GRCz11 (nucleotides) or Jam3b protein (amino acids). (B) Amino acid substitutions in psr mutant alleles relative to Jam3b protein domains. RIE, homophilic interaction domain tripeptide; TM, transmembrane domain; SSFVI, type II PDZ-domain-binding motif (Ebnet, 2017; Ebnet et al., 2004; Kostrewa et al., 2001; Powell and Wright, 2012; Santoso et al., 2005).