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FIGURE 3 Cross-species analysis of cell-type similarity. (A) t-SNE map of zebrafish gill single-cell data. Cells are colored by cell-type cluster. (B) t-SNE map of zebrafish swim bladder single-cell data. Cells are colored by cell-type cluster. (C) Comparative transcriptome analysis of cell similarity between zebrafish gill, swim bladder and mouse lung. Red corresponds to a high correlation; blue and white correspond to low correlation. (D) Comparative transcriptome analysis of cell similarity between gill ionocytes and mouse lung epithelial cells. Zoom-in view of the region highlighted by a solid line in (C). Red corresponds to a high correlation; blue and white correspond to low correlation. Z_SB, zebrafish swim bladder; Z_G, zebrafish gill; M_AL, mouse adult lung; M_FL, mouse fetal lung. (E) A cell–cell correlation network between zebrafish stromal cell and human, mouse fetal, neonatal, adult stromal cells. Thick lines indicate high correlation; thin lines indicate low correlation. H, human; M, mouse; Z, zebrafish. (F) Hierarchical clustering identified correlation of human, mouse and zebrafish stromal cells.