ZFIN Image: Jang et al., 2021, Fig. 1

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Figure Caption

Fig. 1

Epigenetic and transcriptomic dynamics of neural crest cell differentiation into pigment cells. a Schematic of sample collection method and principle component analysis on the DNA methylome, chromatin accessibility, and transcriptome of each cell type. b WashU Epigenome browser views of zebrafish early neural crest marker gene (sox9b), neural crest marker gene (twist1a), melanophore marker gene (tyr), and iridophore marker gene (pnp4a). Grey bars represent CpG sites while height of the blue bars indicates methylation levels. The red box demarcates promoter regions of marker genes. c–e Bar charts illustrating the number of DMRs (c), DEGs (d), and DARs (e) when comparing early NCCs, late NCCs, melanophores, and iridophores. DMRs were identified using DSS (p value < 0.001)

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Acknowledgments

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