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Figure 7
Figure 7. Exposure to LPS or DSS exacerbated the increase in liver size and HCC progression in xmrk+ zebrafish. (A) Quantification and (B) representative images of liver size in xmrk+, xmrk+/LPS, and xmrk+/DSS zebrafish larvae as well as xmrk- siblings at 3 dpt. (C) xmrk+, xmrk+/LPS, and xmrk+/DSS transgenic zebrafish as well as xmrk- control transgenic zebrafish were treated at 4 mpf with 20 μg/mL Dox plus 40 ng/mL LPS or 0.5% DSS, with samples taken at 2 wpi. The left column shows internal abdominal organs with the livers outlined, and the right column depicts H&E staining of liver sections. Scale bar: 50 or 200 μm. (D) Kaplan–Meier survival curves showing days post-induction plotted against percentage survival to 2 wpi. (E) Histological examination confirmed that xmrk+, xmrk+/LPS, and xmrk+/DSS transgenic zebrafish developed HCC at 2 wpi, compared to normal liver histology in xmrk- siblings. Differences among the variables were assessed using Student’s t-tests or one-way ANOVA. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001.
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