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Figure 8 The effects of NOD1 and zfH2A-6 in the defense against S. agalactiae infection. (A) The effect of zfH2A-6 overexpression in the zebrafish larvae on the proliferation of S. agalactiae. (B) The effect of zfH2A-6 on the cell survival in WT and NOD1-deficient cells with S. agalactiae infection. (C) The effect of NOD1 on the antibacterial effect against S. agalactiae infection with or without the existence of zfH2A-6. (D) The transcription regulation of NOD1 on the antibacterial genes in the case of S. agalactiae infection with or without the existence of zfH2A-6. Data are expressed as mean ± SEM of three independent experiments. * p < 0.05; ** p < 0.01; ns—not significant. The asterisk above the error bars indicate statistical significance using the group transfected with empty plasmid as the control group. The asterisk above the bracket indicate statistical significance between the two groups connected by the bracket. (E) NOD1 interacts with zfH2A-6. The interaction between FLAG and GFP or zfH2A-6 is used as the negative controls.