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Fig 1
Immunoglobulin domains composing the CEACAM ectodomains are displayed as oval spheres (in red for Ig-V domains; in light or dark grey for A-type or B-type Ig-C2 domains, respectively). Single-pass transmembrane helices are represented by blue, rounded rectangles. GPI anchors are shown in cyan. Cytoplasmic ITIM (Immunoreceptor Tyrosine-based Inhibitory Motif) and ITAM-like (Immunoreceptor Tyrosine-based Activation Motif) motifs are highlighted in green and orange, respectively. Purple arrows indicate the CEACAMs for which several isoforms have been characterized.
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