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Figure Caption
Figure 4 Disturbance of sphingolipid metabolism in CHM patients. (A) General sphingolipid metabolism pathway with compounds differentially detected in CHM patients highlighted in red (increased) or green (decreased) compared with control levels. (B–I) Scatter dot plots of key metabolite levels in both control (blue) and choroideremia (red) plasma samples. Lines indicate mean ± SD (n = 25). P value was determined using matched pair t tests. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001. SM, sphingomyelin.
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