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Figure 1 Global metabolomic analysis of choroideremia (CHM) patients versus age- and sex-matched controls. (A) Principal component analysis (PCA). Control and CHM samples are represented as blue and red circles, respectively (n = 25 each group). (B) Cluster analysis of control and CHM samples show no clear separation between groups. (C) Top 30 metabolites detected by random forest analysis based on importance to group separation. (D) Pathway analysis calculated using MetaboLync pathway analysis (MPA) software. Pathways with MPA score higher than 1 were considered.
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