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Fig. 3 TCPMOH exposures increase the incidence of embryonic defects and decrease swim bladder inflation. Embryos were individually examined microscopically, daily from 1 to 7 dpf. The most common deformities presented were pericardial edema (A) and yolk edema (impaired yolk utilization) (B) manifesting as an inflated pericardial sac due to fluid retention and inflated, malformed yolk sac, respectively. Decreased (C) swim bladder inflation occurred in a concentration-dependent trend. Increased incidence of craniofacial malformations (D), presenting mostly as lower jaw deformities, were increased in the 1 µM exposure group. Fisher's exact tests were used to assess differences in frequencies between groups. Asterisks (*) indicate statistically significant changes from controls (p<0.05). n = 20–38 embryos per exposure group.v