Figure 1.

Figure 1.

Prion proteins of zebrafish Prp1, Prp2, human PrP^C and Prp1^{ua5003/ua5003} and Prp2^{ua5001/ua5001} mutant proteins. Zebrafish prion protein genes are larger however have the same conserved domains as human PRNP: the repeat domain (green), hydrophobic centre region (orange), hydrophobic tail (blue), N-linked glycosylation sites (blue lines) and di-sulphide bridge (orange lines). The prp1^{ua5003/ua5003} and prp2^{ua5001/ua5001} alleles have frameshift deletions near the beginning of the coding exon, leading to a missense sequence of amino acids (yellow), pre-mature stop codons (red) and a shortened, nonsense transcript