ZFIN Image: Asakawa et al., 2020, Fig. S1

Image

Figure Caption

Fig. S1 The structure of human and zebrafish Tardbp/TDP-43 proteins. RRM, RNA-recognition motif. IDR, intrinsically disordered region. (b, c) The tardbp-n115 and tardbpl-n94 mutations are frame-shift deletions that cause protein truncation. The deleted nucleotides were indicated by red lower cases. The grey bars indicate ectopically added peptide due to the frame shift. (d) The lateral views of the wild type (top) and double homozygous (bottom) larvae at 48 hpf. The arrow and arrowhead indicate the swollen heart and the stacked red blood cells on the far side of the yolk, respectively. The bar indicates 250 μm. (e) Rescue rate of the blood circulation defect of the tardbp-n115 tardbpl-n94 homozygotes (DKOs). The numbers on the histograms show the total numbers of DKOs investigated (Source data are provided as a Source Data file). Error bars show SD.

Figure Data

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.