ZFIN Image: Oh et al., 2019, Figure 1.

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Figure Caption

Figure 1.

Generation of Tg (ela3I-CRE; LSL-KRAS^G12D) fish. (A) Schematic diagram of Tg (ela3I-CRE) driver lines and Tg (LSL-KRAS^G12D) reporter lines. Open triangles indicate Tol2 arms. (B) Confocal images of the microdissected pancreas (5 dpf) in Tg (ela3I-CRE; LSL-KRAS^G12D). GFP signal was detected mainly in the membrane of the pancreas and partly in the cytoplasm as a surrogate marker of KRAS^G12D activation. In the control group (w/o ela3I-CRE), GFP signal was not detected. Asterisk (*) indicates the auto fluorescence of the gut. Scale bar: 25 µm.

Acknowledgments

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