ZFIN Image: Sofou et al., 2021, Figure 7

Image

Figure Caption

Figure 7 Zebrafish embryos deficient in <italic>vps16</italic> demonstrate abnormalities in LROs and myelination

A

Schematic representation of the HOPS complex, indicating the high amino acid identity between human and zebrafish for each subunit.

B

Comparison of control and vps16 embryos at 5 dpf. Compared with control, vps16 embryos have reduced pigmentation in the skin and retinal pigment epithelium and do not develop a swim bladder (arrows). Magnified views show altered melanocyte morphology on the head and pale, translucent eyes.

C, D

Myelination, as reported using the Tg(mbp:gfp‐caax) transgenic, is significantly reduced in vps16 crispants. The yellow box indicates the region assessed in (D). Scale bar 100 μm. Bar graphs represent data as mean ±SEM. Statistical comparisons by Mann–Whitney U‐tests (n = 6). **P < 0.01.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ EMBO Mol. Med.