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Fig. 7 Smooth muscle within the OFT is absent in RA-deficient embryos. (A?D) IHC of Elnb (green) and Mhc (red) in hearts of (A,B) WT sibling and nls mutant embryos and (C,D) DMSO- and DEAB-treated embryos at 72 hpf. Number of embryos examined per condition: WT n ?= ?6, nls n ?= ?8, DMSO-treated n ?= ?12, DEAB-treated n ?= ?9. Views are lateral with arterial pole of the heart up. Arrows indicate the Elnb in WT sibling and DMSO-treated and the lack of Elnb in nls mutant and DEAB-treated at the arterial poles of the hearts. Scale bar ? 50 ??m.
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Reprinted from Developmental Biology, 473, Duong, T.B., Holowiecki, A., Waxman, J.S., Retinoic acid signaling restricts the size of the first heart field within the anterior lateral plate mesoderm, 119-129, Copyright (2021) with permission from Elsevier. Full text @ Dev. Biol.