ZFIN Image: Czimer et al., 2021, FIGURE 4

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Figure Caption

FIGURE 4

Significant differences in between Abcc6b.1 and canonical ABCC6 sequences. (A) Homology model of ABCC6, with conserved residues that are changed in Abcc6b.1 highlighted. (B) Alignment of multiple ABCC6 orthologs with the P654Q change highlighted by the red box. (C) Alignment of multiple ABCC6 orthologs with the E1266G change highlighted by the red box. These alignments show that P654 and E1266 are almost universally conserved across vertebrates, suggesting that they are important for the function of ABCC6. (Alignments of residues highlighted in cyan in A are detailed in Supplementary Figure 4).

Acknowledgments

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