Fig. 1

Fig. 1

a Representative H&E sections from control and Pcm1^−/− brains. Scale 1 mm (b) Representative Cresyl violet histological sections from two WT and two Pcm1^−/− brains depicting enlarged ventricles in the mutant. c Lateral ventricle volume by stereology (N = 3; p = 0.047). Scale 0.4 mm (d) Representative slices from adult WT and Pcm1^−/− brain MRIs. Scale 0.6 mm (e) Representative volumetric views of the lateral ventricles. f Lateral ventricle volume (N = 3; p = 0.036). g Total brain size (N = 4 and 6); p = 0.05). h Total brain volume (N = 4 and 6; p = 0.05). i Representative volumetric views of the cortex. j Cortex volume (N = 3; p = 0.035). k Cortical neuron density (N = 4; p = 0.045). l Representative volumetric views of the striatum (anterior view, shown with transparent cortex). m Striatal volume (N = 3; p = 0.027). Data presented as mean ± SEM; *p < 0.05, WT vs. Pcm1^−/−. Two-sided t-tests, without adjustments. Source data and detailed statistical information are provided as a Source Data File.