ZFIN Image: Zhang et al., 2020, Figure 4

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Figure 4

Spinal cord regeneration in mvp KO fish. (A) Proliferation of neural cells in control and mvp^−/− animals on 7 day post-injury (dpi), assessed by PCNA staining. Bar graph showing percentage of proliferating neural cells in control (n = 6) and mvp^−/− (n = 6) fish. epi, injury epicenter. (B) Upper panel, spinal cord structure of transected site by 30 dpi. Lower panel, retrograde tracing of axonal projections using Fluoro-Ruby (FR). Regenerating axons spanned the transection injury in both control fish (6/6) and mvp^−/− fish (4/5; p < 0.05). Asterisks indicate injury epicenter. In A and B, scale bars = 100 um. (C) Representative swim tracking of individual animals. (D) Quantification of total distance (mean ± SEM, n = 6 for each group) and speed in (C). n.s, not significant.

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Acknowledgments

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