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Fig. 4 Fig. 4. CFTR I556V mutants fail to rescue nkx2.5-expressing cardiac progenitor cells at the 8-somite stage (13 hpf) of embryogenesis. (A) Embryo orientations: dorsal view with anterior at the top. Arrows point to the normal nkx2.5 signal; arrowheads demonstrate the aberrant strength and position of nkx2.5 expression induced by cftr mutants; double-ended arrows indicate the distance between the two nkx2.5+ progenitor populations. Relative expression of nkx2.5 (B) and relative distance of nkx2.5 lateral signal (C) are represented in the scatter diagram.
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Reprinted from Mechanisms of Development, 163, Liu, Y., Lin, Z., Liu, M., Liao, H., Chen, Y., Zhang, X., Chan, H.C., Zhou, B., Rao, L., Sun, H., CFTR deficiency causes cardiac dysplasia during zebrafish embryogenesis and is associated with dilated cardiomyopathy, 103627, Copyright (2020) with permission from Elsevier. Full text @ Mech. Dev.