ZFIN Image: Chetty et al., 2020, Fig. 7

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Figure Caption

Fig. 7 Inhibition of MAPK signaling during vasculogenesis exacerbates angiogenic defects in Etv2-deficient embryos. (A–D) Compound microscope images of 48 hpf Tg(kdrl:GFP) wild-type and etv2 MO (5 ng)-injected embryos treated either with DMSO or 15 μM MAPK inhibitor SL327. Note the severe ISV sprouting defects in etv2 MO + SL327 embryos (D) compared to etv2 MO + DMSO embryos (C). (E,F) Quantitative analysis of ISV number and height. Note the decrease in total number of ISVs (E) and percentage of full sprouts (F) in etv2 MO + SL327 embryos compared to etv2 MO + DMSO embryos. ∗P < 0.05, ∗∗∗P < 0.001. Horizontal bar within violin plots represents median.

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Acknowledgments

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Reprinted from Developmental Biology, 465(1), Chetty, S.C., Sumanas, S., Ets1 functions partially redundantly with Etv2 to promote embryonic vasculogenesis and angiogenesis in zebrafish, 11-22, Copyright (2020) with permission from Elsevier. Full text @ Dev. Biol.