ZFIN Image: Chetty et al., 2020, Fig. 3

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Fig. 3 Loss of Ets1 function impairs vasculogenesis in Etv2-deficient embryos. (A?D) Confocal micrographs of 28 hpf Tg(kdrl:GFP; kdrl:nls-mCherry) wild-type, ets1?/?, etv2 MO (0.25 ?ng) and ets1?/?; etv2 MO (0.25 ?ng) zebrafish embryos (trunk region). (E) Quantitative analysis of endothelial cell number in the axial vessels of embryos in A-D by cell counts in Imaris. (F) FACS analysis of GFP ?+ ?endothelial cells in 28 hpf embryos. Note the decrease in endothelial cell number between etv2 MO and ets1?/?; etv2 MO embryos (E,F). Lateral views; anterior is to the left. ?P ?< ?0.05, ???P ?< ?0.001; n.s ? not significant; error bars represent ?� ?SEM.

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Acknowledgments

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Reprinted from Developmental Biology, 465(1), Chetty, S.C., Sumanas, S., Ets1 functions partially redundantly with Etv2 to promote embryonic vasculogenesis and angiogenesis in zebrafish, 11-22, Copyright (2020) with permission from Elsevier. Full text @ Dev. Biol.