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Fig. 6 Fig. 6. Expression of endocardial genes is reduced or absent in itga4;itga5 double mutants at later stages. (A–C) nfatc1 expression is reduced or absent in the endocardium of itga4;itga5 double mutants compared to siblings and WT at 48 hpf. (D–F) notch1b expression in the AV canal endocardium is absent in itga4;itga5 double mutants compared to siblings and WT at 48 hpf. (G–I) klf2a expression in the AV canal endocardium is absent in itga4;itga5 double mutants compared to siblings and WT at 52 hpf. Frontal views, arrowheads indicate AV canal region of the endocardium.
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Reprinted from Developmental Biology, 465(1), Schumacher, J.A., Wright, Z.A., Owen, M., Bredemeier, N.O., Sumanas, S., Integrin α5 and Integrin α4 cooperate to promote endocardial differentiation and heart morphogenesis, 46-57, Copyright (2020) with permission from Elsevier. Full text @ Dev. Biol.