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Fig. 4 Characterization of camk2g1 mutant zebrafish. Electropherograms of exon2 in wild type and camk2g1 “TALEN” mutant embryos show a loss of 8 nts from wild type (−8) and gain of 6 nts in camk2g1 mutants (+6) leading to a premature stop codon shown for the predicted amino acid sequence from the start codon (A). Camk2g1 mutants appear phenotypically normal at 22 s (B, C), 48hpf (D, E) and 4dpf (F, G). CaMKII specific activity (nmoles/min/mg) is reduced by 25–30% at 48hpf and 72hpf in camk2g1 mutants (H).
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Reprinted from Gene, 742, Rothschild, S.C., Ingram, S.R., Lu, F.I., Thisse, B., Thisse, C., Parkerson, J.A., Tombes, R.M., Genetic compensation of γ CaMKII, an evolutionarily conserved gene, 144567, Copyright (2020) with permission from Elsevier. Full text @ Gene