ZFIN Image: Veerman et al., 2019, Fig. 6.

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Figure Caption

Fig. 6.

ACh induces more pronounced effects in S81L^homo compared to WThuman SAN pacemaker cells in computer simulations. (A-C) Spontaneous APs (blue lines) and associated net membrane current (I_net, gray lines), hyperpolarization-activated ‘funny current’ (I_f, green lines) and I_K,ACh (red lines) in a WT human SAN pacemaker cell at baseline (A), upon addition of 10 nmol l⁻¹ ACh (B) and upon addition of 10 nmol l⁻¹ ACh in the presence of XEN-R0703 (C). (D-F) Spontaneous APs and associated I_net, I_f and I_K,ACh in an S81L^homo human SAN pacemaker cell at baseline (D), upon addition of 10 nmol l⁻¹ ACh (E) and upon addition of 10 nmol l⁻¹ ACh in the presence of XEN-R0703 (F).

Acknowledgments

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