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Figure 1-S1
Reduction of cell-ECM interactions leads to precocious neural tube convergence and rescues cdh2 mutant neural tube convergence defects.
Each column shows a series of transverse sections in 12–14 somite stage embryos along the anterior-posterior axis of the tailbud starting from the last somite boundary (0 μm) in WT (A), cdh2-/- mutants (B), MZ itgα5-/- mutants (C), cdh2-/-; MZ itgα5-/- mutants (D), and fn1a-/; fn1b-/-mutants. (A–D) Immunostaining for FN (red) and nuclei labeling (grey). (E) F-actin labeling (green), and nuclei labeling (red). Yellow dotted lines delineate neural tube contours. Dorsal is to the top. Scale bars = 70 μm.
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