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Figure 7
Schematic representation of hypothesized activities and interactions between Mmp11 and Timp4 paralogues at early and late MTJs. The hemopexin-like domain of Mmp11a interacts with the C-terminal domain of Timp4b in the early MTJ, facilitating the degradation of fibronectin. In the mature MTJ, Mmp11b is inhibited by Timp4a, constraining its activity in the maintenance of the ECM, while Mmp11a localizes to the Z-discs of the sarcomeres within the myocytes.
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Full text @ J Dev Biol