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Fig. S8
Tg(mKO2-zCdt1(1/190)) embryos were treated with 0.5 μM PD0332991 or 0.2 μM CYC202 from the shield stage to the 10-somite stage. Then, these embryos were harvested for in vivo confocal imaging. Note that both PD0332991 and CYC202 treatments induced a remarkable increase of the number of mKO2-zCdt1–positive cells. Scale bar, 200 μm. CDK, cyclin-dependent kinase; EF1α, eukaryotic translation elongation factor 1α; mKO2, monomeric Kusabira Orange2; Tg, transgene; zCdt1, zebrafish chromatin licensing and DNA replication factor 1.
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