ZFIN Image: Lekk et al., 2019, Fig. 3

Image

Figure Caption

Fig. 3

sox1a^-/- mutants show a double-right habenular phenotype.

(A–D”) Dorsal views of the epithalami of wild-type (A–D), sox1a mutant (A’–D’) and parapineal-ablated (A’’–D’’) larvae at 4 dpf showing expression of Tg(foxD3:GFP)^zf104and Tg(flh:eGFP)^U711 transgenes (grey) in the pineal (p) and the parapineal (pp). Habenular mRNA expression of genes indicated on the left is shown in magenta (lHb – left habenula, rHb – right habenula, asterisk – residual asymmetry). Scale bar 25 µm. (E–E”) Dorsal (left images) and lateral (right images) views of the midbrain interpeduncular nucleus (IPN) labelled by anterograde tracing of axons from left dorsal habenula (lHb, green) and right dorsal habenula (rHb, magenta) at 4 dpf. Note the loss of dorsal IPN (dIPN) innervation by the left habenula in the sox1a^-/-mutant (E’) and parapineal-ablated larva (E”). Scale bars 25 µm.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

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Fig. 3

Fig. 3

sox1a-/- mutants show a double-right habenular phenotype.

sox1a^-/- mutants show a double-right habenular phenotype.