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Fig. 6
Lack of response to KT11 in kras/L-ARKO zebrafish during liver tumor progression. (A) Representative images of the gross observations (top), histology images (middle) and PCNA staining (bottom) from male kras and kras/L-ARKO zebrafish treated with Dox with or without KT11. Livers are outlined by a dashed line. (B) Quantitative analyses of histological phenotypes. (C) Quantification of liver cell proliferation based on PCNA staining. Statistical significance between the krasand kras/L-ARKO groups for the incidence of different tumor types: *p < 0.05; **p < 0.01; NS: not significant.
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