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Fig. 8
nedd8-null adult zebrafish are more sensitive to SVCV infection than WT zebrafish. (A,B) nedd8-null zebrafish (3 mpf; 0.38 ± 0.02 g) and the WT (3 mpf; 0.38 ± 0.02 g) were each i.p. injected with 10 μL SVCV (~2 × 108 TCID50/ml) at 0 day. (C,D) At 1 day post-injection (dpi), there were no obvious differences between the WT (nedd8+/+) and nedd8-null zebrafish (nedd8−/−). (E,F) At 2 dpi, the WT zebrafish appeared normal, but the nedd8-null zebrafish had more swelling and hemorrhagic symptoms in the abdomen (indicated by red arrows).
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Full text @ Front Immunol