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Figure 7—figure supplement 2.

ID: ZDB-IMAGE-190723-1084
Source: Figures for Gálvez-Santisteban et al., 2019

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Figure Caption

Figure 7—figure supplement 2. Endocardial specific inhibition of Notch signaling blocks post-injury activation of <italic>bmp10</italic> and <italic>nrg1.</italic>

Whole-mount in situ hybridizations of heat-shocked (HS) (A, B, E, F) vmhc:mCherry-NTR; hsp70l:RS-dnM or (C, D, G, H) vmhc:mCherry-NTR; kdrl:Cre; hsp70l:RS-dnM hearts show that dnMAML endocardial expression can block (D, H) bmp10 and nrg1 (n = 3/19 bmp10; 0/8 nrg1) activation after ventricle-injury at 48 hpt (7 dpf) when compared to (B, F) ventricle-ablated control hearts (n = 21/21 bmp10; n = 18/19 nrg1). V, ventricle; A, atrium; dpf, days post-fertilization; hpt, hours post-MTZ/DMSO treatment. Dashed lines outline the heart.

Acknowledgments

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