ZFIN Image: Rocker et al., 2019, Fig. 3

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Fig. 3

Acute hyperglycemia affects ensheathment by the perineurium. A: in control ins:NTR;Tg(nkx2.2a:megfp) fish 7 days postfertilization (dpf), the perineurium is present in regular intervals (asterisks) along the spinal cord. NTR, nitroreductase; megfp, monomeric enhanced green fluorescent protein. B: following the schedule of treatment described in Fig. 1A, nkx2.2a⁺ perineurial glia in ins:NTR;Tg(nkx2.2a:megfp) fish are stalled at the motor exit point along the spinal cord (white arrows) and are occasionally observed in ectopic locations (arrowhead). MTZ, metronidazole. Scale bar = 50 μm. C: percentage of nerves in which perineurial glia were present was higher in control than MTZ-treated fish. ****P < 0.0001. D: fewer nerves were properly ensheathed by the perineurium in MTZ-treated than control fish. ****P < 0.0001. E: perineurial segments along the peripheral nerve were shorter in MTZ-treated than control fish. ****P < 0.0001.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Am. J. Physiol. Regul. Integr. Comp. Physiol.